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 Technologies

INTELLiVENT®-ASV®. Your bedside assistant

Graphic illustration: four dark light bulbs and one lit light bulb

Go to the next level! The value of INTELLiVENT-ASV

Our intelligent ventilation mode turns you from a knob-turner into a supervisor. INTELLiVENT-ASV reduces the number of manual interactions with the ventilator (Beijers AJ, Roos AN, Bindels AJ. Fully automated closed-loop ventilation is safe and effective in post-cardiac surgery patients. Intensive Care Med. 2014;40(5):752-753. doi:10.1007/s00134-014-3234-71​, Bialais E, Wittebole X, Vignaux L, et al. Closed-loop ventilation mode (IntelliVent®-ASV) in intensive care unit: a randomized trial. Minerva Anestesiol. 2016;82(6):657-668. 2​, Fot EV, Izotova NN, Yudina AS, Smetkin AA, Kuzkov VV, Kirov MY. Automated Weaning from Mechanical Ventilation after Off-Pump Coronary Artery Bypass Grafting. Front Med (Lausanne). 2017;4:31. Published 2017 Mar 21. doi:10.3389/fmed.2017.000313​), and supports individualized lung-protective ventilation for your patients (Bialais E, Wittebole X, Vignaux L, et al. Closed-loop ventilation mode (IntelliVent®-ASV) in intensive care unit: a randomized trial. Minerva Anestesiol. 2016;82(6):657-668. 2​, Fot EV, Izotova NN, Yudina AS, Smetkin AA, Kuzkov VV, Kirov MY. Automated Weaning from Mechanical Ventilation after Off-Pump Coronary Artery Bypass Grafting. Front Med (Lausanne). 2017;4:31. Published 2017 Mar 21. doi:10.3389/fmed.2017.000313​, Arnal JM, Saoli M, Garnero A. Airway and transpulmonary driving pressures and mechanical powers selected by INTELLiVENT-ASV in passive, mechanically ventilated ICU patients. Heart Lung. 2020;49(4):427-434. doi:10.1016/j.hrtlng.2019.11.0014​). From intubation to extubation.

Ventilation modes ASV (left side) and INTELLiVENT-ASV (right side)

How is it different? A paradigm shift

In conventional modes, you set multiple ventilator controls like tidal volume or pressure, respiratory rate, FiO2, PEEP, and expiratory and inspiratory time to achieve certain clinical targets. And all those controls need frequent readjustment.

With INTELLiVENT-ASV, your defined clinical targets and strategies for oxygenation and ventilation are at the center. Once you have set them, you can decide to what extent INTELLiVENT-ASV should control oxygenation and ventilation in order to reach them.

INTELLiVENT-ASV then automatically selects ventilator settings, manages the transition between passive and active states, and actively supports your weaning protocols using Quick Wean.

Graphic illustration: an intubated patient with a doctor beside them

Is it for my patients? For intubated adult and pediatric patients

Multiple international studies have demonstrated the safety and performance of INTELLiVENT-ASV in various clinical scenarios - from post-cardiac surgery (Beijers AJ, Roos AN, Bindels AJ. Fully automated closed-loop ventilation is safe and effective in post-cardiac surgery patients. Intensive Care Med. 2014;40(5):752-753. doi:10.1007/s00134-014-3234-71​) to COVID-19 pneumonia (Wendel Garcia PD, Hofmaenner DA, Brugger SD, et al. Closed-Loop Versus Conventional Mechanical Ventilation in COVID-19 ARDS. J Intensive Care Med. 2021;36(10):1184-1193. doi:10.1177/088506662110241395​), and for various specific conditions such as COPD (Arnal JM, Saoli M, Garnero A. Airway and transpulmonary driving pressures and mechanical powers selected by INTELLiVENT-ASV in passive, mechanically ventilated ICU patients. Heart Lung. 2020;49(4):427-434. doi:10.1016/j.hrtlng.2019.11.0014​), brain injury (Sulemanji DS, Marchese A, Wysocki M, Kacmarek RM. Adaptive support ventilation with and without end-tidal CO2 closed loop control versus conventional ventilation. Intensive Care Med. 2013;39(4):703-710. doi:10.1007/s00134-012-2742-66​), and ARDS  (Arnal JM, Saoli M, Garnero A. Airway and transpulmonary driving pressures and mechanical powers selected by INTELLiVENT-ASV in passive, mechanically ventilated ICU patients. Heart Lung. 2020;49(4):427-434. doi:10.1016/j.hrtlng.2019.11.0014​).

Laurent Buscemi Dr. Adrian Wäckerlin

Customer voices

We gain time by using INTELLiVENT-ASV, which we can use to accomplish other important tasks that take place in an ICU, such as taking care of the patients and providing essential medical care.

Laurent Buscemi

ICU Nurse
Intercommunal Hospital, Var Departement, France

Customer voices

The concept from Hamilton Medical to establish automated ventilation in the ICU is certainly a step in the right direction. We use INTELLiVENT-ASV as a standard ventilation mode since 2010.

Dr. Adrian Wäckerlin

Head of ICU, Grisons Cantonal Hospital
Grisons Cantonal Hospital, Chur, Switzerland

Dr. Jean-Michel Arnal, Senior Intensivist Dr. Jean-Michel Arnal, Senior Intensivist

How does it work? INTELLiVENT-ASV explained at the bedside

In this video, Dr. Jean-Michel Arnal, Senior Intensivist, gives you a quick demonstration of the main functionalities and settings in INTELLiVENT-ASV on a real ICU patient.

Graphic illustration: dart aims at target

Ready, aim, ventilate! How to get started

At the beginning, you set the patient's height, gender, and specific condition: normal lungs, ARDS, chronic hypercapnia, or brain injury. Next, you set the clinical targets in terms of oxygenation (SpO2) and CO2 elimination (PetCO2) for your patient.

 

You then have various options to fine-tune INTELLiVENT-ASV. For example, you can decide whether you want to set PEEP manually or if you want INTELLiVENT-ASV to set PEEP within a range defined by you. After reviewing or setting alarm limits, you are ready to start ventilation.

Graphic illustration: dart hits target

Keeping the patient on target. How to adjust ventilation

INTELLiVENT-ASV implements your strategy at the bedside. Instead of making frequent changes to individual settings, you monitor and readjust the targets and strategy when necessary.

 

INTELLiVENT-ASV brings the patient into your defined target range and then keeps them there - while maintaining lung-protective ventilation (Bialais E, Wittebole X, Vignaux L, et al. Closed-loop ventilation mode (IntelliVent®-ASV) in intensive care unit: a randomized trial. Minerva Anestesiol. 2016;82(6):657-668. 2​, Fot EV, Izotova NN, Yudina AS, Smetkin AA, Kuzkov VV, Kirov MY. Automated Weaning from Mechanical Ventilation after Off-Pump Coronary Artery Bypass Grafting. Front Med (Lausanne). 2017;4:31. Published 2017 Mar 21. doi:10.3389/fmed.2017.000313​, Arnal JM, Saoli M, Garnero A. Airway and transpulmonary driving pressures and mechanical powers selected by INTELLiVENT-ASV in passive, mechanically ventilated ICU patients. Heart Lung. 2020;49(4):427-434. doi:10.1016/j.hrtlng.2019.11.0014​). It constantly adjusts individual ventilator controls (such as rate, tidal volume, inspiratory pressure, PEEP, and FiO2), and switches between controlled and assisted ventilation - all based on physiologic inputs that are evaluated with every breath.

 

These inputs are provided by three sensors: The proximal flow sensor provides data on lung mechanics and patient activity, while the SpO2 and CO2 sensors provide data on oxygenation and CO2 elimination.

Statistical graphic: 3 phases of how a patient is weaned

Let’s get them off! How to wean your patients

Use INTELLiVENT-ASV's Quick Wean to implement your weaning protocol. You can enable Quick Wean at any time before or during ventilation.

You can configure Quick Wean to perform controlled spontaneous breathing trials (SBTs) according to your protocols: You adjust the criteria for starting an SBT, the settings to be used while the SBT is running, and the criteria for aborting it.

INTELLiVENT-ASV always displays the history of all performed SBTs. If an SBT is unsuccessful, INTELLiVENT-ASV reverts to the previous ventilation settings.

Experts On Air INTELLiVENT-ASV: Up close and personal

Webinar series starting December 15

Join the experts as they tell their stories about the many different faces of INTELLiVENT-ASV.

Statistic graphic: Lellouche F. Intensive Care Med. 2013 Mar;39(3):463-471.

What are the benefits? A look at the evidence

Clinical studies have shown that INTELLiVENT-ASV selects safe driving pressure (Arnal JM, Saoli M, Garnero A. Airway and transpulmonary driving pressures and mechanical powers selected by INTELLiVENT-ASV in passive, mechanically ventilated ICU patients. Heart Lung. 2020;49(4):427-434. doi:10.1016/j.hrtlng.2019.11.0014​), safe mechanical power (Arnal JM, Saoli M, Garnero A. Airway and transpulmonary driving pressures and mechanical powers selected by INTELLiVENT-ASV in passive, mechanically ventilated ICU patients. Heart Lung. 2020;49(4):427-434. doi:10.1016/j.hrtlng.2019.11.0014​), and safe tidal volume (Lellouche F, Bouchard PA, Simard S, L'Her E, Wysocki M. Evaluation of fully automated ventilation: a randomized controlled study in post-cardiac surgery patients. Intensive Care Med. 2013;39(3):463-471. doi:10.1007/s00134-012-2799-27​).

INTELLiVENT-ASV requires fewer manual adjustments than conventional ventilation and thus helps lower the workload for the healthcare team (Beijers AJ, Roos AN, Bindels AJ. Fully automated closed-loop ventilation is safe and effective in post-cardiac surgery patients. Intensive Care Med. 2014;40(5):752-753. doi:10.1007/s00134-014-3234-71​, Bialais E, Wittebole X, Vignaux L, et al. Closed-loop ventilation mode (IntelliVent®-ASV) in intensive care unit: a randomized trial. Minerva Anestesiol. 2016;82(6):657-668. 2​, Fot EV, Izotova NN, Yudina AS, Smetkin AA, Kuzkov VV, Kirov MY. Automated Weaning from Mechanical Ventilation after Off-Pump Coronary Artery Bypass Grafting. Front Med (Lausanne). 2017;4:31. Published 2017 Mar 21. doi:10.3389/fmed.2017.000313​).

Graphic illustration: students throwing their hats in the air

Good to know! INTELLiVENT-ASV training resources

Availability

INTELLiVENT-ASV is available as an option on the HAMILTON-G5, HAMILTON-C6, HAMILTON-C3, HAMILTON-C1 and HAMILTON-T1, and as a standard mode on the HAMILTON-S1.

References

  1. 1. Beijers AJ, Roos AN, Bindels AJ. Fully automated closed-loop ventilation is safe and effective in post-cardiac surgery patients. Intensive Care Med. 2014;40(5):752-753. doi:10.1007/s00134-014-3234-7
  2. 2. Bialais E, Wittebole X, Vignaux L, et al. Closed-loop ventilation mode (IntelliVent®-ASV) in intensive care unit: a randomized trial. Minerva Anestesiol. 2016;82(6):657-668.
  3. 3. Fot EV, Izotova NN, Yudina AS, Smetkin AA, Kuzkov VV, Kirov MY. Automated Weaning from Mechanical Ventilation after Off-Pump Coronary Artery Bypass Grafting. Front Med (Lausanne). 2017;4:31. Published 2017 Mar 21. doi:10.3389/fmed.2017.00031
  4. 4. Arnal JM, Saoli M, Garnero A. Airway and transpulmonary driving pressures and mechanical powers selected by INTELLiVENT-ASV in passive, mechanically ventilated ICU patients. Heart Lung. 2020;49(4):427-434. doi:10.1016/j.hrtlng.2019.11.001

 

  1. 5. Wendel Garcia PD, Hofmaenner DA, Brugger SD, et al. Closed-Loop Versus Conventional Mechanical Ventilation in COVID-19 ARDS. J Intensive Care Med. 2021;36(10):1184-1193. doi:10.1177/08850666211024139
  2. 6. Sulemanji DS, Marchese A, Wysocki M, Kacmarek RM. Adaptive support ventilation with and without end-tidal CO2 closed loop control versus conventional ventilation. Intensive Care Med. 2013;39(4):703-710. doi:10.1007/s00134-012-2742-6
  3. 7. Lellouche F, Bouchard PA, Simard S, L'Her E, Wysocki M. Evaluation of fully automated ventilation: a randomized controlled study in post-cardiac surgery patients. Intensive Care Med. 2013;39(3):463-471. doi:10.1007/s00134-012-2799-2

Footnotes

 

Fully automated closed-loop ventilation is safe and effective in post-cardiac surgery patients.

Authors: Ashley J R Beijers, Arnout N Roos, Alexander J G H Bindels

Closed-loop ventilation mode (IntelliVent®-ASV) in intensive care unit: a randomized trial.

Authors: Emilie Bialais, Xavier Wittebole, Laurence Vignaux, Jean Roeseler, Marc Wysocki, Johannes Meyer, Gregory Reychler, Dominik Novotni, Thierry Sottiaux, Pierre F Laterre, Philippe Hantson

Automated Weaning from Mechanical Ventilation after Off-Pump Coronary Artery Bypass Grafting.

Authors: Evgenia V Fot, Natalia N Izotova, Angelika S Yudina, Aleksei A Smetkin, Vsevolod V Kuzkov, Mikhail Y Kirov

Airway and transpulmonary driving pressures and mechanical powers selected by INTELLiVENT-ASV in passive, mechanically ventilated ICU patients.

Authors: Jean-Michel Arnal, Mathieu Saoli, Aude Garnero

Closed-Loop Versus Conventional Mechanical Ventilation in COVID-19 ARDS.

Authors: Pedro David Wendel Garcia, Daniel Andrea Hofmaenner, Silvio D Brugger, Claudio T Acevedo, Jan Bartussek, Giovanni Camen, Patrick Raphael Bader, Gregor Bruellmann, Johannes Kattner, Christoph Ganter, Reto Andreas Schuepbach, Philipp Karl Buehler

Adaptive support ventilation with and without end-tidal CO2 closed loop control versus conventional ventilation.

Authors: Demet S Sulemanji, Andrew Marchese, Marc Wysocki, Robert M Kacmarek

Evaluation of fully automated ventilation: a randomized controlled study in post-cardiac surgery patients.

Authors: François Lellouche, Pierre-Alexandre Bouchard, Serge Simard, Erwan L'Her, Marc Wysocki