Journal Club: Effect of personalized MV on clinical outcomes in ARDS patients

Author: Belal Al-Rajoub, Reviewer: Bernhard Schmitt

Does a personalized ventilation strategy affect outcomes in ARDS patients?

There is still uncertainty about the effects of higher PEEP and recruitment maneuvers (RMs) in ARDS patients. However, we do know that these patients are not the same and therefore clinicians should consider ARDS phenotypes when setting the ventilator. In this review, we look at the LIVE study from France, which was the first of its kind to investigate this question. This multicenter, randomized controlled trial compared a ventilation strategy personalized to the patient’s lung morphology with the standard of care in terms of outcomes in ARDS patients. Click on the image to view the video presentation.



Constantin JM, Jabaudon M, Lefrant JY et al. Personalised mechanical ventilation tailored to lung morphology versus low positive end-expiratory pressure for patients with acute respiratory distress syndrome in France (the LIVE study): a multicentre, single-blind, randomised controlled trial. The Lancet Respiratory Medicine. 7. 10.1016/S2213-2600(19)30138-9.

PEEP, recruitment maneuvers, RMs, ARDS, LIVE study, personalized ventilation, personalized strategy

Date of Printing: 21.04.2021
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