The choice of tube size for uncuffed tubes is commonly made according to Cole`s formula (Age/4 + 4 mm); for cuffed tubes a size 0.5 mm smaller is recommended. The cuff pressure needs to be sufficient to avoid leakage during mechanical ventilation, as well as to completely seal the airway and prevent micro-aspiration (thus preventing ventilator-associated pneumonia).
However over-inflation, particularly over a prolonged period, may limit mucosal perfusion. The standard cuff pressure to provide leakage-free ventilation is usually set at 25 mbar. Absence of leakage is primarily essential in special situations such as during a recruitment maneuver. In all other circumstances, common practice in many PICU`s is to keep the cuff inflated to provide minimal leakage at peak inspiratory pressure, so that cuff pressure can usually be down-titrated to values between 20–25 mbar.
Cuff pressure leak thresholds in children will vary with sedation status and positioning of the patient, and are also influenced by coughing and suctioning. Pressure drops occur within a few hours after manual adjustment of the cuff pressure. Therefore, regular monitoring of the cuff pressure to provide accurate cuff pressure control is very important. This can be best achieved with an online cuff controller tool such as Intellicuff.
A pre-extubation leak pressure test may provide information about the risk of a subglottic upper airway obstruction occurring. Because the cuff is located in the subglottic area, the cuff leak pressure threshold appears to measure subglottic edema. A simple method of gaining this information is to test whether an audible leak occurs at a peak inspiratory pressure of 25 mbar, after the patient has been suctioned and the cuff has been deflated. The presence of an audible pre-extubation leak at 25 mbar indicates that no subglottic upper airway obstruction will occur, whereas the absence of leak at 25 mbar signals a subglottic stenosis that will need treatment in 18%–19% of patients. The importance of leakage in the case of cuffed endotracheal tubes may be related to the fact that in comparison to uncuffed tubes, the cuffed tubes used are usually smaller because the cuff can be inflated to maintain tidal volume and pressure.
Figure 1: An 18-month old child ventilated with a Ppeak of 24 cmH2O (PEEP 10 cmH2O). IntelliCuff is set to auto control. The cuff pressure is set at -4 cmH2O in relation to Ppeak. The cuff pressure lower limit is 12 cmH2O; the upper limit 26 cmH2O.
Figure 2: An 8-year old child with severe ARDS ventilated with a Ppeak of 35 cmH2O and PEEP of 22 cmH2O. IntelliCuff is set to manual control. The cuff pressure is titrated to 23 cmH2O to allow a minimum leak (4%).
- Evidence Based Use of Cuffed Endotracheal Tubes in Children. Herbinger LA. Journal of PeriAnesthesia Nursing, Vol 33, No 5 (October), 2018: pp 590-600.
- Calder A, Hegarty M, Erb TO, von Ungern-Sternberg BS. Predictors of postoperative sore throat in intubated children. Paediatr Anaesth. 2012;22(3):239-243.
- Newth CJ, Rachman B, Patel N, Hammer J. The use of cuffed versus uncuffed endotracheal tubes in pediatric intensive care. J Pediatr. 2004; 144(3):333-7.
- Schneider J, Mulale U, Yamout S, Pollard S, Silver P. Impact of monitoring endotracheal tube cuff leak pressure on postextubation stridor in children. J Crit Care. 2016;36:173-177.
- Laboratory Evaluation of Cuff Pressure Control Methods. Babic SA and Chatburn RL. Respir Care. 2019 Jul 30. pii: respcare.06728. doi: 10.4187/respcare.06728. [Epub ahead of print]
- Khemani RG, Hotz J, Morzov R, Flink R, Kamerkar A, Ross PA, Newth CJ. Evaluating Risk Factors for Pediatric Post-extubation Upper Airway Obstruction Using a Physiology-based Tool. Am J Respir Crit Care Med. 2016 Jan 15;193(2):198-209.
- Chung YH, Chao TY, Chiu CT, Lin MC. The cuff-leak test is a simple tool to verify severe laryngeal edema in patients undergoing longterm mechanical ventilation. Crit Care Med 2006;34:409–414.
- Should cuffed endotracheal tubes be the first-line choice for intubation in pediatric intensive care units?
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