This randomized crossover trial included 30 patients with an average age of 21 months and heterogenous lung conditions. The investigators at the Dr Behcet Uz Children's Disease and Surgery Training and Research Hospital in Izmir, Turkey, ventilated them with standard Adaptive Support Ventilation® settings for two phases. During one, the INTELLiVENT-ASV FiO2 controller was activated and during the other, FiO2 was titrated manually. Minute ventilation and PEEP were maintained at the same level during the two phases.
Compared with manual FiO2 titration, activation of the FiO2 controller resulted in:
These findings indicate the potential for greater efficiency with closed-loop FiO2 control - not only in terms of oxygen requirements, but also in terms of the number of adjustments possible without increasing the staff's workload.
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